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Sertraline perfect serotonin inhibitors of reuptake (SSRI) belongs to a class of drugs of called. Other drugs in this class - Prozac (fluoxetine), Paxil (paroxetine), Celexa (citalopram) and Luvox (fluvoxamine). Serotonin - a mediator (the chemical messenger) made by cells of a nerve in a brain, which is prescribed by nerves to communicate with each other. The nerve releases serotonin whom it makes in a place environmental it. serotonin or travel across a place and the attache in receptors on a surface of nearby nerves or it attaches to receptors on a surface of a nerve which has made it to be taken a nerve and released again (the process named as re-uptake). Balance achieve serotonin between the appendix to nearby nerves and reuptake. Perfect inhibitors of serotonin block reuptake of serotonin and consequently change a level of serotonin in a brain. It is necessary, that there are some illnesses such as depression are caused by disorders in balance between serotonin and other mediators. The conducting theory - that drugs such as sertraline restores chemical balance among mediators in a brain. Sertraline has been approved by the Foodstuffs and Administration of the prescription in December 1991.
Tablets: 25, 50, and 100 mg; an oral concentrate: 20 mg / ml
Sertraline is a prescription, which is prescribed to consider depression, the possessed - persuasive disorder, the panic disorder, and the post-traumatic disorder of a pressure. Similarly to another SSRIs, sertraline also is prescribed to consider the social disorder of anxiety and postmenstrual dysphoric the disorder.
Serious reactions such as hyperthermia, fluctuations in a blood pressure and rigidity of muscles can take place, when SSRIs are prescribed in a combination with monoamine oxidase inhibitors (MAOI) such as phenelzine, tranylcypromine (Parnate) and isocarboxazid. Therefore, SSRIs it should not be prescribed in a combination with MAOIs. Besides SSRIs and MAOIs the friend after the friend should not be prescribed within 14 days.
Tagamet can increase levels in blood sertraline, reducing elimination sertraline to cookies. The increased levels sertraline can conduct to a lot of side effects.
Sertraline increases a level of blood pimozide (Orap) by 40 %. Highly levels pimozide can mention electric conductivity in heart and messages to sudden death. Therefore, patients should not receive treatment both with pimozide and with sertraline.
Through unknown mechanisms, sertraline can increase blood, thinning action of warfarin. The effect of warfarin should be checked up, when sertraline is started or stopped.
The most common side effects sertraline - drowsiness, nervousness, insomnia, dizziness, a nausea, concussion, a precipitate skin, a stomach of frustration, loss of appetite, a headache, the diarrhea, wrong exclamation, a dry mouth and loss of weight. The important side effects - irregular palpation, allergic reactions and activation of mania in patients with the bipolar disorder.
If sertraline is stopped sharply, it is a little attributes of experience of patients such as belly spasmes, a flu it is similar to attributes, weariness and memory impairment. Though this reaction well is not established, reasonably gradually to reduce a dose when therapy is stopped.
It was offered, that SSRIs can force to worsen depression and even messages to suicide in a small amount of patients. These potential side effects are difficult to estimate in the oppressed patients because depression can, progress with or without treatment, and suicides - the consequence of depression is independent. Besides evidence supporting these potential side effects is weak. Therefore, any conclusions cannot be nevertheless drawn about relations between SSRIs both worsening depression and suicide. While the best information is not accessible, the patients receiving SSRIs should be checked up to worsen depression and terrible tendencies.
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